Anthracyclines areused inthe adjuvant treatment ofbreast cancerfor about 25 years.Recentlyin the light ofnew data ontaxanesandtargeted therapies(trastuzumab) that have proventheir effectiveness andthe emergenceof newpredictorsof sensitivity toanthracyclines, it wasasked the following questions: 1.Isit possibleto dispense withanthracyclinesandtaxanesfor the benefit oftargeted therapies?! 2.Should weprescribeto all patientsanthracyclines?! 3.Isthere anypredictive factorsfor selectingpatientswho will benefitmost fromanthracyclines.